Indica vs. Sativa – Is there even a difference? Sativa and Indica are two main species of cannabis plants that have thousands of subspecies known as strains. They are commonly hailed by distributors and recreational users for having their own distinct benefits and effects. For the longest time, I thought that all strains of cannabis must be one of three types. Indica strains that are said to have a sedative relaxing affect, sativa strains known to provide a more uplifting cerebral affect…and of course hybrid strains which are thought to possess qualities of both indica and sativa……..RIGHT?